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Buy Avanafil Spedra online

The advantage of avanafil over other PDE-5 inhibitors is its rapid onset of action and high selectivity.
Maximum plasma levels of Avanafil are reached within 30 to 45 minutes, the half-life is six to 17 hours.

In comparison:

• Avanafil (Spedra®): 30 to 45 minutes, half-life: six to 17 hours
• Sildenafil (Viagra®): 30 to 120 minutes, half-life: three to five hours
• Tadalafil (Cialis®): 120 minutes, half-life: 17.5 hours ("weekend pill")
• Vardenafil (Levitra®): 30 to 120 minutes, half-life: four to five hours

Avanafil also acts highly selectively on phosphodiesterase 5, and its effect on PDE-5 is much stronger than on other known phosphodiesterases.
The factor of about 20,000 higher selectivity for PDE-5 compared to PDE-3 is important because PDE-3,
an enzyme found in heart and blood vessels, is involved in controlling cardiac contractility.

In comparison:

• Avanafil: 20,000 times higher selectivity to PDE-5 than PDE-3
• Sildenafil: > 4000-times higher selectivity compared to PDE-5 than PDE-3
• Tadalafil: > 10,000 times higher selectivity compared to PDE-5 than PDE-3
• Vardenafil: > 1000 times higher selectivity compared to PDE-5 than PDE-3

The more than 100 times higher selectivity of avanafil for PDE-5 compared to PDE-6 is also clinically significant, as the latter occurs in the retina and is responsible for phototransduction there.
Changes in colour vision, e.g. in sildenafil, are caused by inhibition of PDE-6.

In comparison:

• Avanafil: > 100 times higher selectivity to PDE-5 than PDE-6
• Sildenafil: 10 times higher selectivity compared to PDE-5 than PDE-6
• Tadalafil: > 700 times higher selectivity to PDE-5 than PDE-6
• Vardenafil: > 15 times higher selectivity to PDE-5 than PDE-6