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_TB-500
Thymosin beta-4 (TB-500) accelerates wound healing, muscle fibers and their cells, promotes muscle recovery.
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TB-500 is a synthetic version of the thymosin beta-4 peptide, which naturally occurs in virtually all human and animal cells. This potent peptide is a member of the ubiquitous family of 16 related molecules with a highly conserved sequence found in most tissues and cells circulating in the body. The TB-500 binds to actin, blocks actin polymerization and represents the actin-sequestering molecule in eukaryotic cells. TB-500 has been identified as a gene that has increased 4 to 6 fold during the early stage of blood vessel formation. This peptide is present in the morning fluid. Helps to create new blood cells from existing vessels, accelerates wound healing, muscle fibers and their cells, promotes muscle recovery.
Another key factor in the TB-500 is that it helps cell migration by specific interaction with actin in the cytoskeleton of the cell. It has been shown that the central domain consisting of small amino acids that binds long actin has properties that promote blood cell replication and wound healing. These properties reveal the accelerated migration of endothelial cells and keratinocytes. It also increases the production of enzymes that degrade the extracellular matrix.
Studies suggest that the TB-500 is a potent, naturally occurring factor that heals wounds and has an anti-inflammatory effect. T-ß-4 differs from other healing factors, such as growth factors, because it supports the migration of endothelial cells and keratinocytes. It does not bind to the extracellular matrix and has a very low molecular weight, so it can move over the tissues over a relatively long distance. One of the key mechanisms of action of the TB-500 is the ability to regulate the actin protein, which is an important part of the cellular structure, involved in cell formation and movement. Among the thousands of proteins present in the cells, actin represents up to 10% of the total protein component, therefore plays a major role in the genetic makeup of the cell.
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